These data reinforce the involvement of the nitric oxide and endocannabinoids (anandamide) in #stress-related disorders and point to a deregulation of the endocannabinoid system in situations where nitric oxide signaling is increased.
Nitric oxide (NO) is of critical importance as a mediator of vasodilation in blood vessels. That plays a role in development and maintenance of penile #erection.
Nitric oxide also acts on cardiac muscle to decrease contractility and #heart rate. Emerging evidence suggests that coronary artery disease (CAD) is related to defects in generation or action of NO. Diminished supply of nitric oxide can lead to vascular damage, such as endothelial dysfunction and vascular inflammation.
Diabetes patients usually have low levels of Nitric Oxide.
The discovery of the biological functions of nitric oxide in the 1980s was unexpected. Missing link? The endocannabinoid system was also founded in the human body and brain in the 1980s. Nitric oxide was named “Molecule of the Year” in 1992 by the journal Science, a Nitric Oxide Society was founded, and a scientific journal devoted entirely to nitric oxide was established. The Nobel Prize in Physiology or Medicine in 1998 .